2Department of Ophthalmology, Private Atanur Eye Hospital, Isparta, 32040, Türkiye DOI : 10.37844/glau.cat.2023.18.2 Purpose: To investigate the possible link between hematological and atherogenic indices reflecting inflammation and cardiovascular risk and exfoliation syndrome (XFS) and exfoliation glaucoma (XFG).
Materials and Methods: This study included a total of 83 participants (29 XFS, 25 XFG, and 29 healthy controls) who were scheduled for routine cataract surgery. Blood sampling was performed from the individuals and complete blood count (CBC), C-reactive protein (CRP), uric acid (UA), and serum lipids were measured. Neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), monocyte/high-density lipoprotein cholesterol (HDL-c) ratio (MHR), and platelet/lymphocyte ratio (PLR) were also calculated. Examined parameters were compared statistically.
< b>Results: Statistically significant higher white blood cells, neutrophil count, UA and triglyceride (TG) levels were determined in the XFG group. NLR and MLR were significantly higher in the XFS and XFG groups compared to the control group. MHR was significantly higher in the XFG group than the control group. Lymphocyte count was significantly lower in the XFS and XFG groups compared to the control group. HDL-c was significantly lower in the XFG group compared to the other two groups. Furthermore, receiver operating curve analysis revealed that lymphocyte count, NLR, MLR, MHR, and HDL-c had significant predictive value for XFS, and NLR, MHR, and HDL-c for XFG.
Conclusion: In the light of current knowledge, XFS is a multisystem entity. This study results revealed that there was a link between XFS/XFG and hematological and atherogenic parameters reflecting inflammation and cardiovascular risk and these parameters may be important in the follow-up of XFS/XFG and related diseases.
Keywords : Exfoliation syndrome, Glaucoma, Inflammation, Hematological indices, Atherogenics indices