2Prof. Dr., MD, Ondokuzmayıs University Faculty of Medicine, Ophtalmology Department, Samsun, Turkey DOI : 10.37844/glauc.cat.2022.17.6 Purpose: To determine the retinal nerve fiber layer thickness (RNFLT) and macular ganglion cell analysis (mGCA) of healthy individuals with large physiological cupping.
Materials and Methods: This cross-sectionally designed study was managed in a single-centered eye clinic. Eyes with large physiological cupping were defined as group 1 with cup to disc ratio (CDR) >0.3. The second group was defined as those CDR £0.3. The mGCA and RNFLT measurements were obtained by spectral-domain optical coherence tomography (SD-OCT).
Results: The mean age of 43 patients (23 women, 20 men) with large physiological cupping was 34.6 ± 15.3 years and 44 patients (25 women, 19 men) with normal cupping was 33.27 ± 14.75 years. The central macular thickness (CMT) values were similar between two groups (p=0.1). The average and three quadrant measurements of RNFL showed significant difference between two groups, except nasal quadrant. However, the average and five quadrant measurements of GCA showed similar results between two groups, except inferotemporal quadrant. While the correlation analysis determined significantly negative correlation between CDR and mean and three quadrants of RNFLT, there was no correlation between CDR and mean and any quadrants of GCA.
Conclusion: As a result the measurements of macular GCA should be thought more valuable parameter than peripapillary RNFLT to evaluate the pathological processes.
Keywords : Large physiological cupping, Ganglion cell analysis, Retinal nerve fiber layer, Optical coherence tomography, Optic nerve