2M.D. Associate Professor, Canakkale Onsekiz Mart University, School of Medicine, Department of Ophthalmology, Canakkale/TURKEY
3M.D. Associate Professor, Gazi University, School of Medicine, Department of Ophthalmology, Ankara/TURKEY Purpose: To determine the short-term intraocular pressure (IOP) and anterior segment alterations following intravitreal injection of antivascular endothelial growth factor (anti-VEGF).
Materials and Methods: A prospective series of consecutive patients undergoing injection of 0.05 mL intravitreal bevacizumab or ranibizumab, without vitreous reflux, was investigated. IOP measurements were performed using Tono-Pen. Anterior segment parameters including anterior chamber depth (ACD), anterior chamber volume (ACV) and anterior chamber angle (ACA) were measured with the Sirius Scheimpflug camera. Measurements were obtained in each eye just before the injection, 5 minutes after the injection and 24 hours after the injection.
Results: A total of 42 eligible patients were included in this study. Mean baseline IOP was 15.9±3 mmHg and it increased to 25.9±10.5 mmHg 5 minutes after the injection (p<0.001). 24 hours after the injection, IOP normalized with a value of 15±3.4 mmHg (p>0.05). Compared with baseline, changes in ACD and ACV were statistically non-significant at each time-point (p>0.05). The mean ACA decreased from 38±6.7˚ at baseline to 36.7±7.1˚ five minutes after injection (p=0.004). Mean ACA value normalized at 24 hours with a value of 37.6±7.1˚ (p>0.05).
Conclusion: Anterior segment parameters, except ACA, seem to be unchanged after intravitreal injection. The alterations in ACA returned to normal values with the decrease of IOP values after 24 hours of injection.
Keywords : Intravitreal injection; intraocular pressure; anterior chamber depth; anterior chamber volume; anterior chamber angle