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Automated Perimetry
Carbonic Anhydrase Inhibitors
Intra Ocular Lens Power Calculation and Optic Biometry...
Visual Field Defects in Glaucoma
Visual Field Defect and Retinal Nerve Fiber Layer Defect in a Case of Optic Nerve Head Drusen...
Current Minimal Invasive Angle Procedures Without Implants for the Treatment of Glaucoma...
Intra Ocular Lens Power Calculation and Optic Biometry...
Automated Perimetry
Carbonic Anhydrase Inhibitors
Visual Field Defect and Retinal Nerve Fiber Layer Defect in a Case of Optic Nerve Head Drusen...
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TJ-CEO 2006 , Vol 1 , Num 4
Turkish Abstract Abstract PDF Similar Articles Mail to Author
The Results of Subconjunctival Injection of Low Dose 5-Fluorouracil for Failing Filtration Blebs after Trabeculectomy and Evaluating the Factors that Affecting the Outcome
Tülay ŞİMŞEK 1, Yasemin ÖZDAMAR 1, Aygen BATMAN 1, Ufuk ELGİN 1, Jale KARAKAYA 2, Orhan ZİLELİOĞLU 3
1Ulucanlar Göz Eğitim ve Araştırma Hastanesi, Ankara, Uzm. Dr.
2Hacettepe Üniversitesi, Tıp Fakültesi, Biyoistatistik A.D., Ankara, Araş. Gör.
3Ulucanlar Göz Eğitim ve Araştırma Hastanesi Klinik Şefi, Ankara, Uzm. Dr.
Purpose: To investigate the effectiveness of subconjunctival low dose 5-fluorouracil injection (5-FU) in the management of bleb failure after trabeculectomy.

Materials and Methods: Forty eyes of 40 patients with bleb failure after trabeculectomy were included in this study. Repeated doses of 5mg of 5-fluorouracil (5-FU) were injected subconjunctivally in eyes with bleb failure after filtering surgery. The success was defined as an intraocular pressure (IOP) of ≤21 mmHg with or without medications. Intraocular pressure, the number of eyes using antiglaucomatous medications, frequency of 5- FU injection, variations of bleb appearance and complications were evaluated prospectively during the follow-up period.

Results: Primary open angle glaucoma in 12 eyes (30%), neovascular glaucoma in 10 eyes (25%), narrow angle glaucoma in 3 eyes (7.5%) and secondary glaucoma in 15 eyes (37.5%) were detected. When a decision of applying 5-FU injection was reached, mean IOP was 26.2±7.1mmHg. The mean IOP was 17.0±9.0 mmHg at the last follow-up examination. There was statistically significant difference between the pre-treatment and post-treatment IOP (p<0.001). 5-FU application was more successful in patients with primary glaucoma (p<0.05). Overall rate was 91.6% at 3 months, 85.7% at 6 months, 80% at 12 months and 63.6 %at 18 months. Follow-up time was 3-18 months. Punctate epiteliopathy in 9 (22.5%) eyes and corneal ulcers in 5 (12.5%) eyes were observed during follow-up period.

Conclusions: Low dose 5-FU application appears to improve bleb function in patients with bleb failure after trabeculectomy. Procedure is more successful in patients with primary glaucoma. The modified administration of 5-FU can result in fewer corneal complications. Keywords : Trabeculectomy, failing filtering bleb, 5-fluorouracil

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