2M.D. Associate Professor, Mustafa Kemal University Faculty of Medicine, Department of Ophthalmology, Hatay/TURKEY Purpose: To evaluate the efficacy and safety of ketorolac 0.5% ophthalmic solution to control postoperative inflammation in pediatric cataract surgery.
Materials and Methods: Forty one eyes of 41 children with congenital or developmental cataract were included in the study. The subjects were assigned to receive topical ketorolac 0.5% ophthalmic solution preoperatively and postoperatively (group 1) or without ketorolac 0.5% ophthalmic solution (group 2). Each patient had uneventful phacoemulsification with a placement of a foldable posterior chamber intraocular lens. Follow-up visits were performed 1, 3, 7 and 30 days postoperatively. The postoperative inflammation or associated complications such as cyclitic membrane, intraocular lens precipitates, anterior and posterior synechia and optic capture were evaluated for each group by slit-lamp examination and compared.
Results: There were significant differences in terms of inflammatory cells in the anterior chamber between group 1 and group 2 at follow-up visits that performed postoperatively 1st, 3rd and 7th day (p<.05). Although significant differences were found between groups in aspect of the flare at postoperative 1st and 3rd day visits (p<.05), there was no significant difference at 7th day visit (p>.05). In 6 patients from group 2 had inflammatory related complications including cyclitic membrane, posterior synechia, intraocular lens precipitates and optic capture. There was not statistically significant difference in terms of intraocular pressure between groups.
Conclusion: Ketorolac 0.5% solution seems effective and safe when started before surgery and continued 1 month postoperatively for the treatment of the postoperative inflammation in children.
Keywords : Cataract, ketorolac, pediatric, inflammation, surgery