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¹GATA Haydarpaşa Eğitim Hastanesi Göz Hastalıkları Servisi, İstanbul, Yrd. Doç. Dr.
²GATA Haydarpaşa Eğitim Hastanesi Göz Hastalıkları Servisi, İstanbul, Doç. Dr.
³İ.Ü. Cerrahpaşa Tıp Fakültesi Halk Sağlığı A.D., İstanbul, Uzm. Dr.
⁴GATA Haydarpaşa Eğitim Hastanesi Göz Hastalıkları Servis, İstanbul, Uzm. Öğr. Dr.
⁵GATA Haydarpaşa Eğitim Hastanesi Göz Hastalıkları Servis Şefi, İstanbul, Prof. Dr. Purpose: Spectral-domain optic coherence tomography (OCT) is a new imaging device that can provide cross-sectional images with a higher resolution and shorter scanning time comparing to time-domain OCTs. In this study we investigated the reproducibility and reliability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained with Spectral OCT/SLO which is a new generation OCT.
Materials and Methods: Fourteen right eyes of 14 normal subjects were enrolled to the study. Peripapillary RNFL (diameter: 3.4 mm) was imaged using spectral OCT three times per visit without pupil dilation. These measurement series were repeated on three days within a week. In each peripapillary RNFL scan, 13 different thickness measurements were calculated, including mean RNFL thickness, four quadrant thicknesses (superior, inferior, nasal, and temporal), and 8 clock quadrant thicknesses. The reproducibility of three measurements performed in a visit day (intravisit) and three measurements performed in three visit days (intervisit) were assessed using the intraclass correlation coefficient (ICC) and standard deviation (SD).
Results: The mean RNFL thickness was 114.8±11.6 μm. According to the ICC and SD values that we analyzed to assess the reproducibility, the intravisit and intervisit measurements showed a high reproducibility. ICC and SD values were between 82 and 95%, 1.0 and 4.1 μm in intravisit measurements, between 75 and 88%, 2.1 and 5,8 μm in intervisit measurements respectively. The best ICC and SD values were found for the mean RNFL thickness measurements (intravisit ICC: 95%, SD: 1.0 μm; intervisit ICC: 88%, SD: 2.1 μm). the intravisit and intervisit reproducibility was highest in the inferior quadrant among the four quadrants (from highest to lowest; inferior, temporal, superior, and nasal quadrant).
Conclusion: The spectral OCT/SLO which is a new generation OCT demonstrated reproducible measurements of RNFL thickness without pupil dilation. The best reproducibility was found for the mean RNFL thickness measurements. Keywords : Spectral-domain OCT, peripapillary RNFL, reproducibility