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Tamoxifen is an anti-estrogen agent used in therapy of the breast cancer. A number of ocular complications such as maculopathy have been described secondary to tamoxifen therapy. We report a case of bilateral intraocular pressure rise observed during tamoxifen therapy in a 50-yearold woman with primary open angle glaucoma which has not been previously reported. Rapid decline of intraocular pressure in both eyes was achieved by means of cessation of tamoxifen and administered oral acetazolamide therapy. Here, we aim to attract attention among ophthalmologists and oncologists a possible adverse effect of tamoxifen therapy. Keywords : Intraocular pressure, primary open angle glaucoma, tamoxifen, estrogen, breast cancer