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¹S.B. Ankara Ulucanlar Göz Eğitim Hastanesi II. Göz Kliniği, Ankara, Doç. Dr.
²S.B. Ankara Ulucanlar Göz Eğitim Hastanesi II. Göz Kliniği, Ankara, Asist. Dr.
³S.B. Ankara Keçiören Eğitim Hastanesi Biyokimya Bölümü, Ankara, Uzm. Dr.
⁴S.B. Ankara Ulucanlar Göz Eğitim Hastanesi II. Göz Kliniği, Ankara, Uzm. Dr. Purpose: A prospective, comparative study was carried out to investigate the concentration of endothelin-1 (ET-1) in the aqueous humor (HA) of cases patients with pseudoexfoliation glaucoma (PXG) and, pseudoexfoliation syndrome (PEX) and in normal subjects, and to compare the results with each other.
Materials and Methods: HA samples were obtained from 13 eyes with PXG, 18 eyes with PXS, and 14 eyes of normal subjects at the beginning of trabeculectomy, phakoemulsificationphacoemulsification, or combined surgery. ET-1 concentration in HA was measured by enzyme-linked immunoassay. Mann-Whitney U test and Kruskal Wallis analysis of variance test were used for the statistical analysis.
Results: The mean HA concentration of ET-1 was 7.49±1.05 pg/ml in the eyes with PXG, 7.45±1.41 pg/ml in the eyes with PXS, and 3.92±1.83 pg/ml in the control eyes. The ET-1 levels of both PXG and PXS cases patients were found to be statistically significantly higher than those of the control subjects (p<0.01); but no significant difference was found between PXG and PXS cases patients (p=0.95).
Conclusion: Our results support a role for high ET-1 HA concentration in the etiopathology of PXG and PXS. However, no difference between the HA levels of ET-1 of the eyes with PXG and PXS was detected and further investigations with a larger number of cases were planned. Keywords : Endothelin-1, aqueous humor, pseudoexfoliation glaucoma, pseudoexfoliation syndrome