Material and Methods: Ninety-five eyes from 95 patients with early-stage POAG (latanoprost 0.005% (n=35), travoprost 0.004% (n=30), bimatoprost 0.01% (n=30)) and a healthy control group (n=35) were included in this cross-sectional study. Retinal nerve fiber layer (RNFL) thickness and radial peripapillary capillary (RPC) VDs were measured using 4.5x4.5 mm ONH sections of the patients. Superficial capillary plexus (SCP) VDs, deep capillary plexus (DCP) VDs, and retinal thickness values were measured using 6x6 mm macular sections centered on the fovea.

Results: Peripapillary retinal thickness (ppRT), whole image VD (wiVD), and peripapillary VD (ppVD) measurements were significantly higher in the control group compared to the groups receiving PGA monotherapy (p=0.005, p=0.006, and p=0.002, respectively). SCP and DCP foveal VD (fVD) values were significantly higher in the bimatoprost 0.01% group (p=0.001 and p=0.010, respectively). No significant difference was observed between wiVD, parafoveal VD (pafVD), and perifoveal VD (pefVD) groups in both SCP and DCP (p>0.05). Additionally, in the bimatoprost 0.01% group, while foveal retinal thickness (fRT) was significantly thicker (p=0.005), whole image retinal thickness (wiRT) and perifoveal retinal thickness (pefRT) were significantly thinner (p=0.016, and p=0.009, respectively). Parafoveal retinal thickness (pafRT) was also thinner but not significantly so in the bimatoprost group (p=0.312).

Conclusion: The increased foveal blood flow in users of bimatoprost compared to those using latanoprost and travoprost may indicate that bimatoprost 0.01% positively affects ocular perfusion. Keywords : latanoprost 0.005%, travoprost 0.004%, bimatoprost 0.01%, primary open angle glaucoma, optical coherence tomography angiography